SNAP-8 10 mg (Acetyl Octapeptide-3) from Peptide Tech is a premium, lyophilized research-use-only (RUO) peptide supplied at ≥99% purity (HPLC & MS verified). This linear octapeptide (Ac-EEMQRRAD-NH2) is frequently used in in-vitro SNARE-related biochemistry, peptide analytics, and membrane-fusion model systems where sequence fidelity, analytical confirmation, and batch traceability are critical.
Specifications
| Property | Details |
|---|---|
| CAS Number | 868844-74-0 |
| Chemical Name | Acetyl Octapeptide-3 (SNAP-8); INCI: Acetyl Glutamyl Heptapeptide-3 |
| PubChem CID | 86080331 |
| Molecular Formula | C41H70N16O16S |
| Molecular Weight | ≈ 1075.16 g/mol |
| Physical Appearance | White to off-white lyophilized powder |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (Ac-EEMQRRAD-NH2) |
| Container | 3 mL glass vial (10 mg net content) |
| Purity | ≥99% verified by HPLC & MS (lot COA via on-vial QR) |
| Solubility | Readily soluble in sterile water or compatible buffers; prepare fresh. Due to Met residue, minimize exposure to oxidants and strong UV; work quickly at neutral pH. |
| Intended Use | Laboratory research only (RUO). Not for human or animal use. |
Molecular Structure
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Potential Applications in Research
Strictly in-vitro, cell-free, or cell-based experiments. No health claims or clinical/veterinary use.
- SNARE-mediated liposome fusion assays (lipid/content mixing) to probe effects on reconstituted v/t-SNARE assembly and fusion kinetics in defined proteoliposome systems.
- FRET-based SNARE complex assembly measurements (e.g., labeled SNAP-25/VAMP/Syntaxin constructs) to quantify assembly/disassembly dynamics in real time.
- Exocytosis model workflows in neuronal or neuroendocrine cell lines (e.g., dye-based vesicle release readouts) under controlled depolarization and Ca2+ conditions.
- Analytical method development (RP-HPLC and LC–MS/MS) for identity, stability, and matrix-recovery of acetylated peptides in buffered systems.
- Peptide–material interaction screens (e.g., inorganic cluster/polyoxometalate systems) to characterize non-covalent assembly and adhesion-related properties in vitro.
Quality, Storage & Handling
Every lot is confirmed by HPLC (purity) and MS (identity); batch-level COA is accessible via on-vial QR. Independent U.S. labs verify purity, quantity, and endotoxin.
- Storage (lyophilized): −20 °C long-term or 2–8 °C short-term; keep desiccated and protected from light.
- After reconstitution: Aliquot and store at ≤−20 °C; avoid repeated freeze–thaw cycles.
- Reconstitution tips: Use sterile water or suitable buffer; gentle inversion to dissolve; 0.22 µm filter only if required by your SOP.
Shipping & Fulfillment
Ships with validated cold-chain packaging. In-stock orders placed before the daily cutoff ship the same day. 2-Day FedEx/UPS is standard, with overnight options available. Automated text/email updates included; international shipping available where permitted.
Compliance & RUO Disclaimer
For laboratory research only. Not a drug, cosmetic, food, or household chemical. Not for human or animal use, diagnostic, or therapeutic applications. Buyers warrant they are qualified to handle RUO materials under applicable laws and institutional guidelines.
FAQs
- Is this intended for human or veterinary use?
- No. This product is sold strictly as RUO and must not be used in humans or animals.
- What purity do you provide?
- Each 10 mg vial is ≥99% by HPLC with MS identity confirmation; third-party testing is performed on every lot (see COA via QR).
- How should I reconstitute it?
- Use sterile water or compatible buffer; gently invert until fully dissolved. If your protocol requires sterility, pass through a 0.22 µm filter and aliquot to avoid repeat freeze–thaw.
- Which in-vitro assays is SNAP-8 commonly used in?
- Typical RUO uses include reconstituted liposome fusion assays, FRET-based SNARE assembly measurements, dye-tracked exocytosis models, and LC–MS/MS method development.
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