PT-141 (Bremelanotide) — 10 mg Lyophilized Powder (RUO)

PT-141 (USAN: Bremelanotide) is a cyclic heptapeptide melanocortin-receptor agonist supplied by Peptide Tech as a sterile, lyophilized powder in a research vial. Intended strictly for laboratory research use only, PT-141 is suited for in-vitro, cell-based, and analytical workflows exploring MC_1/3/4/5 receptor pharmacology, signaling bias, and stability/method development (no human-use or therapeutic claims).

Specifications

Property	Details
Product Name	PT-141 (Bremelanotide) — 10 mg
Synonyms	PT-141; Bremelanotide
CAS Number	189691-06-3
PubChem CID	CID 9941379
Molecular Formula	C₅₀H₆₈N₁₄O₁₀
Molecular Weight	≈ 1025.18 g/mol
Sequence / Topology	Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH (lactam ring between Asp and Lys)
Form	Lyophilized powder (freeze-dried)
Container	Sterile Type I glass vial; 10 mg net content; QR batch ID
Appearance	White to off-white lyophilized cake/powder
Identity / Purity	Research-grade; MS/HPLC confirmation per lot — see COA
Solubility	Soluble in sterile water or compatible aqueous buffer; optimize pH/ionic strength per assay; filter (0.22 µm) if sterility is required by your protocol
Storage	Store sealed, desiccated, protected from light. Short-term: 2–8 °C. Long-term: ≤−20 °C. After reconstitution, aliquot and avoid repeated freeze–thaw.
Intended Use	For laboratory research use only (RUO); not for human or animal use, ingestion, diagnostic, therapeutic, or veterinary applications.

Molecular Structure

Key Features — Peptide Tech

Same-Day Shipping (Mon–Fri, in-stock)
GMP-Aligned peptide synthesis, lyophilization & packaging
USA Made with QR batch tracking & COA access
Third-Party U.S. Lab Testing — purity, quantity; endotoxin where applicable
Cold-Chain Shipping — Always (no paid upgrade)
Worldwide Shipping with compliant documentation
Text & Email Order Updates; 2-Day FedEx/UPS Standard & economical Overnight options

Potential Applications in Research

Strictly non-clinical; examples below are in-vitro, cell-based, or analytical only (no health or therapeutic claims).

Melanocortin receptor signaling — quantify MC_1/3/4/5 activation in heterologous cell systems via cAMP/CRE-luciferase, Ca²⁺ flux, or ERK/MAPK readouts; compare signaling bias profiles. reference
Radioligand / competition-binding assays — determine affinity/selectivity at melanocortin receptors and derive K_d/K_i values under defined conditions. reference
β-arrestin recruitment & internalization — profile receptor trafficking dynamics vs. other melanocortin ligands using live-cell biosensors. reference
Stability / forced-degradation studies — pH, oxidative, thermal, and light-stress mapping with stability-indicating HPLC/LC-MS methods.
Analytical method development — validate ID/assay methods for cyclic peptides, including recovery, adsorption, and matrix effects across buffers and plastics.

Citations

PubChem Compound Summary: Bremelanotide (PT-141). CID 9941379.
The Merck Index Online — Bremelanotide monograph (formula & MW). Link.
DrugBank. “Bremelanotide: Uses, Interactions, Mechanism of Action.” DB11653.
Liu, Z., et al. “MC4R biased signalling and the conformational basis for ligand function.” Cell Mol Life Sci, 2022. PMC9344818.
(Sequence/topology reference) PT-141 monograph: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH; C₅₀H₆₈N₁₄O₁₀. PDF.

Quality, Storage & Handling

Quality: Each lot confirmed by MS/HPLC (see COA). Third-party testing performed where applicable.
Reconstitution: Bring vial to room temperature; add sterile solvent; swirl gently to dissolve; aliquot promptly.
Post-Reconstitution: Store aliquots at ≤−20 °C; minimize freeze–thaw cycles.

Shipping & Fulfillment

Ships with validated cold-chain packaging. In-stock orders placed before the daily cutoff dispatch the same day. 2-Day FedEx/UPS is standard, with overnight options available. Automated text/email updates included; international service available where permitted.

Compliance & RUO Disclaimer

For laboratory research use only. Not a drug, food, or cosmetic. Not for human or animal use, ingestion, diagnostic, therapeutic, or veterinary applications. Purchasers must be qualified to handle RUO materials and comply with applicable laws and institutional policies.

[1]: https://pubchem.ncbi.nlm.nih.gov/compound/9941379?utm_source=chatgpt.com “Bremelanotide | C50H68N14O10 | CID 9941379”
[2]: https://merckindex.rsc.org/monographs/m12151?utm_source=chatgpt.com “Bremelanotide | The Merck Index Online”
[3]: https://go.drugbank.com/drugs/DB11653?utm_source=chatgpt.com “Bremelanotide: Uses, Interactions, Mechanism of Action”
[4]: https://pmc.ncbi.nlm.nih.gov/articles/PMC9344818/?utm_source=chatgpt.com “MC4R biased signalling and the conformational basis …”
[5]: https://northamptonintegrativemedicine.com/wp-content/uploads/2020/04/PT-141-Monograph.pdf?utm_source=chatgpt.com “Professional Monograph PT-141 (Bremelanotide)”