GLP-1 “S” 5mg

GLP-1 “S” — 5mg (3 mL vial, lyophilized peptide)

GLP-1 “S” (GLP-1 receptor agonist analog) — a 31-amino-acid GLP-1(7–37)–based peptide engineered with an Aib₈ substitution to block DPP-4 cleavage, a Lys₂₆(γ-Glu-[OEG]₂-C18 diacid) acylation to enhance albumin association, and a Lys→Arg substitution at position 34 (GLP numbering), enabling potent GLP-1R engagement in in-vitro GPCR pharmacology. Supplied by Peptide Tech at ≥ 99% purity (HPLC/MS verified) for in-vitro, cellular, and biochemical research use only (RUO). Not for human or veterinary use.

 

Specifications

CAS Number	910463-68-2
Chemical Name	(acylated GLP-1 analog)
PubChem CID	56843331
Molecular Formula	C187H291N45O59
Molecular Weight	≈ 4,113–4,114 g/mol
Sequence	GLP-1(7–37) analog with Aib at position 8; Lys26 acylated via γ-Glu-[OEG]2-C18 diacid; Lys→Arg at position 34; linear peptide (no disulfides). Exact lot sequence details: see COA.
Counter-ion	Acetate (typical; confirm on lot COA)
Physical Appearance	White to off-white lyophilized powder
Container	3 mL Type I glass vial, bromobutyl rubber stopper, aluminum flip-off seal (net content: 5 mg)
Purity	≥ 99% (verified by HPLC & MS; third-party tested)
Solubility	Soluble in sterile water. For concentrated stocks, pre-wet with ≤0.1–5% acetic acid; gently agitate. Consider 0.05–0.1% carrier protein to minimize adsorption; 0.22 µm filter-sterilize if required.

 

Molecular Structure (Reference)

 

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Storage & Handling

• Lyophilized (unopened): Store at ≤ −20 °C, protected from light and moisture. For long-term archival, ≤ −80 °C is recommended.
• After reconstitution: Aliquot into sterile, low-binding tubes; store at ≤ −80 °C. Avoid repeated freeze–thaw cycles.
• Handling: Allow vial to reach room temperature before opening to minimize condensation. Use sterile technique and neutral-pH buffers; consider carrier protein to mitigate surface adsorption.
• Research Use Only (RUO): Not for human or veterinary use, ingestion, diagnostic, or therapeutic applications.

Potential Applications in Research

Strictly in-vitro, cellular, or biochemical contexts — no clinical or human-use claims.

• GLP-1R pharmacology: cAMP accumulation, β-arrestin recruitment, and receptor internalization in heterologous expression systems.
• Biased signaling & pathway profiling: Quantify relative signaling bias (e.g., G_s vs. β-arrestin) versus native GLP-1 and reference analogs.
• Ligand binding/occupancy: Competition and kinetic studies versus GLP-1 and other GLP-1R agonists.
• Structure–function: Evaluate effects of Aib₈ substitution and Lys₂₆ acylation on receptor engagement, trafficking, and stability.
• Formulation/stability: Assess adsorption, aggregation resistance, and excipient impacts under cell-culture conditions.

 

Citations (PubMed)

• Lau, J., et al. “Discovery of the Once-Weekly GLP-1 Analogue Semaglutide.” J Med Chem, 2015. PubMed
• Manandhar, B., et al. “GLP-1 Analogs: Recent Advances in Design and SAR.” J Med Chem, 2015. PubMed
• Zhang, X., et al. “Cryo-EM structures of semaglutide-bound GLP-1R–G_s complexes.” Cell Reports, 2021. Link
• Liu, Q.-K., et al. “Mechanisms of action and therapeutic applications of GLP-1R agonists.” Signal Transduct Target Ther, 2024. PMC

Compliance & RUO Disclaimer

For laboratory research use only (RUO). Not a drug, food, or cosmetic. Not for human or veterinary use. Purchase and use are limited to qualified personnel operating under institutional laboratory guidelines.