GLP-2 “TZ” 10mg
Original price was: $79.99.$59.99Current price is: $59.99.
Discover GLP-2 “TZ” 10 mg, a powerful 39-amino-acid peptide designed for in-vitro research. This dual incretin analog activates GIP and GLP-1 receptors, enhancing peptide stability and persistence in cell studies. Each vial contains 10 mg of lyophilized peptide, with ≥ 99% purity verified by HPLC/MS. Ideal for cellular and biochemical research applications, it’s a must-have for serious scientists looking to advance their studies.
GLP-2 “TZ” — 10 mg (3 mL vial, lyophilized peptide)
A 39-amino-acid, acylated dual incretin analog that activates both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors in in-vitro GPCR pharmacology. Lipidation via a long-chain diacid linker enhances albumin association and peptide persistence in cell-based systems. Supplied by Peptide Tech at ≥ 99% purity (HPLC/MS verified) for in-vitro, cellular, and biochemical research use only (RUO). Not for human or veterinary use.
Specifications
| CAS Number | 2023788-19-2 |
| Chemical Name | Dual GIP/GLP-1 receptor agonist peptide |
| PubChem CID | 156588324 |
| Molecular Formula | C225H348N48O68 (free base) |
| Molecular Weight | ≈ 4,813.5 g/mol (free base) |
| Sequence | 39-aa dual incretin analog with Aib substitutions at positions 2 and 13; Lys20 acylated via γ-Glu–(AEEA)2–C20 fatty diacid; C-terminal amide; linear (no disulfides). Exact lot details: see COA. |
| Counter-ion | Acetate (typical; confirm on lot COA) |
| Physical Appearance | White to off-white lyophilized powder |
| Container | 3 mL Type I glass vial, bromobutyl rubber stopper, aluminum flip-off seal (net content: 10 mg) |
| Purity | ≥ 99% (verified by HPLC & MS; third-party tested) |
| Solubility | Soluble in sterile water; for concentrated stocks, pre-wet with ≤0.1–5% acetic acid and gently agitate. Consider 0.05–0.1% carrier protein to minimize adsorption; 0.22 µm filter-sterilize if required. |
Molecular Structure (Reference)
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Storage & Handling
- Lyophilized (unopened): Store at ≤ −20 °C, protected from light and moisture. For long-term archival, ≤ −80 °C is recommended.
- After reconstitution: Aliquot into sterile, low-binding tubes; store at ≤ −80 °C. Avoid repeated freeze–thaw cycles.
- Handling: Allow vial to reach room temperature before opening to minimize condensation. Use sterile technique and neutral-pH buffers; consider carrier protein to mitigate surface adsorption.
- Research Use Only (RUO): Not for human or veterinary use, ingestion, diagnostic, or therapeutic applications.
Potential Applications in Research
Strictly in-vitro, cellular, or biochemical contexts — no clinical or human-use claims.
- GIPR/GLP-1R pharmacology: cAMP accumulation, β-arrestin recruitment, and receptor internalization in engineered cell systems.
- Biased signaling & pathway profiling: Quantify relative bias vs. selective GLP-1R or GIPR agonists.
- Ligand binding/occupancy: Competition and kinetic studies against mono-agonist comparators.
- Receptor cross-talk: Explore co-expressed GLP-1R/GIPR pathway integration and downstream transcriptional signatures.
- Formulation/stability: Assess adsorption, aggregation resistance, and excipient impacts under cell-culture conditions.
Citations (PubMed)
- Coskun, T., et al. “LY3298176, a novel dual GIP and GLP-1 receptor agonist: from discovery to clinical proof of concept.” Mol Metab, 2018. PMC
- Nauck, M. A., & Quast, D. R. “Tirzepatide, a dual GIP/GLP-1 receptor co-agonist.” Diabetes Obes Metab, 2022. PMC
- Sun, B., et al. “Structural determinants of dual incretin receptor agonism by tirzepatide.” PNAS, 2022. PNAS
- Frias, J. P., et al. “Efficacy and safety of LY3298176, a dual GIP and GLP-1 receptor agonist.” Lancet, 2018. Link
Compliance & RUO Disclaimer
For laboratory research use only (RUO). Not a drug, food, or cosmetic. Not for human or veterinary use. Purchase and use are limited to qualified personnel operating under institutional laboratory guidelines.
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