KPV 5mg – 99% Pure Peptide for Sale Peptide Tech

Elevate your studies with KPV (Lys–Pro–Val), a premium research peptide offered by Peptide Tech at ≥99% purity for precise, reproducible scientific applications. KPV is the C-terminal tripeptide fragment of α-MSH and is widely explored in cell-based and biochemical models where tight control over sequence, purity, and handling conditions matters.

SPECIFICATIONS TABLE

Property: Details
— CAS Number: 67727-97-3
— Chemical Name: L-lysyl-L-prolyl-L-valine (α-MSH 11–13, “KPV”)
— PubChem CID (clickable): PubChem CID 125672 —
— Molecular Formula: C16H30N4O4
— Molecular Weight: 342.43 g/mol
— Physical Appearance: White to off-white lyophilized powder
— Sequence: Lys-Pro-Val (K-P-V)
— Container: 3 mL glass vial (5 mg net content)
— Purity: ≥99% (verified by HPLC & MS)
— Solubility: Readily soluble in sterile water or aqueous buffer (optimize pH/ionic strength for your assay; filter-sterilize if required)

KPV Structure

KPV Biologic Description

WHY PEPTIDE TECH

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• Tested for Every Metric: Purity, Quantity, Endotoxin by certified third-party labs in the USA
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PRODUCT OVERVIEW

KPV is a compact tripeptide (K-P-V) valued for its clean sequence, excellent handling characteristics, and compatibility with a wide range of in-vitro models. Because it’s so small, KPV is popular in pathway interrogation studies (e.g., NF-κB/matrix remodeling signaling readouts), membrane interaction screens, and transporter-mediated uptake experiments using standardized epithelial cell lines. Researchers choose Peptide Tech for the combination of ≥99% purity, validated analytical data, and robust cold-chain fulfillment that helps protect peptide integrity from our facility to your lab bench.

POTENTIAL APPLICATIONS IN RESEARCH

• In-vitro NF-κB pathway studies in airway/bronchial epithelial models (e.g., TNF-α–stimulated reporter assays, IκBα stabilization, nuclear import readouts). (PubMed)
• PepT1-mediated transport investigations in intestinal epithelial cells (Caco-2/HT29 lines), with downstream NF-κB/MAPK signaling measurements and cytokine expression profiling. (PMC)
• Keratinocyte signaling and intracellular calcium response experiments to dissect α-MSH fragment activity without invoking pigmentation endpoints. (PubMed)
• Antimicrobial/antifungal mechanism screens (e.g., S. aureus or Candida models) focusing on membrane effects or synergy hypotheses — strictly in vitro. (PMC)
• Comparative studies of α-MSH core/tripeptide fragments (e.g., KPV vs. related motifs) across cell-based anti-inflammatory readouts to map minimal effective sequences. (PMC)

CITATIONS

Dalmasso, Guillaume, et al. “PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation.” Gastroenterology, vol. 134, no. 1, 2008, pp. 166–178.. (PMC)

Land, Stephen C. “Inhibition of Cellular and Systemic Inflammation Cues in Human Bronchial Epithelial Cells by Melanocortin-Related Peptides: Mechanism of KPV Action and a Role for MC3R Agonists.” International Journal of Physiology, Pathophysiology and Pharmacology, vol. 4, no. 2, 2012, pp. 59–73.  . (PubMed)

Elliott, Richard J., et al. “Alpha-Melanocyte-Stimulating Hormone, MSH 11–13 KPV and Adrenocorticotropic Hormone Signalling in Human Keratinocyte Cells.” Journal of Investigative Dermatology, vol. 122, no. 4, 2004, pp. 1010–1019. (PubMed)

Singh, Manish, et al. “Alpha-Melanocyte Stimulating Hormone: An Emerging Anti-Inflammatory Antimicrobial Peptide.” Journal of Immunology Research, 2014, Article ID 874610. . (PMC)

Storage Guidance: Store lyophilized vials at −20 °C or below; once reconstituted, aliquot and store at −80 °C; avoid >3 freeze–thaw cycles.

FAQ

• Q: Is KPV intended for human or veterinary use?
  A: No. Sold strictly for laboratory research only (RUO). Not for human or animal use, ingestion, or diagnostic purposes.
• Q: What purity do you provide?
  A: Each KPV lot is ≥99% by HPLC with MS identity confirmation and third-party testing; see the lot-matched COA via QR on the vial.
• Q: How is it shipped?
  A: Cold-chain packaging is standard on applicable items; we never upsell cold shipping upgrades.
• Q: What’s the typical solvent?
  A: Sterile water or compatible aqueous buffer; adjust pH/ionic strength to your assay’s requirements.
• Q: Do you price-match?
  A: Yes — submit a qualifying quote and we’ll match it on equivalent grade and terms.

POLICIES & DISCLAIMERS

• Research Use Only (RUO). Not a drug, food, supplement, or cosmetic.
• No statements on this page are intended to diagnose, treat, cure, or prevent any disease.
• Follow your institution’s handling, PPE, waste, and documentation requirements.