CJC-1295 with DAC 2mg

CJC-1295 with DAC (Drug Affinity Complex) — 2 mg is a long-acting analogue of growth hormone–releasing hormone (GHRH 1-29) featuring an N^ɛ-maleimidopropionyl-Lys extension that enables reversible albumin binding for prolonged stability in vitro. Supplied by Peptide Tech at ≥ 99% purity (HPLC/MS verified), this material is intended strictly for in-vitro, cellular, and biochemical research use only (RUO). Key identifiers and structural details are provided below for analytical method development and reproducible assay design.

 

Specifications

CAS Number	446262-90-4
Chemical Name	GHRH(1-29) analogue, Nɛ-maleimidopropionyl-Lys (DAC)–conjugated
PubChem CID	CID 56841945
Molecular Formula	C165H269N47O46
Molecular Weight	≈ 3,647.25 g/mol
Sequence	H-Tyr-DAla-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-(Nɛ-maleimidopropionyl-)Lys-NH2
Physical Appearance	White to off-white lyophilized powder
Container	3 mL glass vial (2 mg net content)
Purity	≥ 99% (HPLC & MS; third-party verified)
Solubility	Soluble in sterile water or compatible aqueous buffer; mix gently until fully dissolved; filter-sterilize (0.22 μm) if required

Molecular Structure

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Storage & Handling

• Lyophilized (unopened): Store at ≤ −20 °C in a dry, dark environment. For long-term archival, ≤ −80 °C is recommended.
• After reconstitution: Prepare sterile aliquots; store at ≤ −80 °C for maximal stability (≤ −20 °C acceptable for short-term studies). Avoid repeated freeze–thaw cycles.
• General notes: Allow vial to equilibrate to room temperature before opening to minimize condensation. Use sterile water or compatible buffer (e.g., PBS); avoid strong acids/bases.
• Research Use Only (RUO): Not for human or veterinary use, ingestion, diagnostic, or therapeutic applications.

Potential Applications in Research

Strictly in-vitro, cellular, or biochemical contexts — no clinical or human-use claims.

• Albumin-binding bioconjugation & receptor activation: DAC-modified GHRH analogues to probe receptor signaling and half-life extension strategies in cell models.
  Jetté et al., 2005.
• Pulsatility under sustained stimulation: Examine GH secretory dynamics during prolonged GHRH-analogue exposure with sampling-based analytics.
  Ionescu & Frohman, 2006.
• PK/PD characterization & dose-response mapping: Reference studies reporting sustained, dose-dependent effects on GH/IGF-I for method benchmarking.
  Teichman et al., 2006.
• Serum proteomics readouts: Investigate downstream protein profile changes following GHRH-R engagement in normal adult subjects (for orthogonal biomarker panels).
  Sackmann-Sala et al., 2009.
• Preclinical systems biology: Use knockout models for assay development and growth-related endpoint confirmation (non-clinical).
  Alba et al., 2006.
• Analytical detection workflows: Build immuno-independent LC-HRMS/MS methods and metabolism panels for GHRH analogues in matrices.
  Coppieters et al., 2022;
  Memdouh et al., 2021.

Citations (PubMed)

• Jetté, L., et al. “Human Growth Hormone-Releasing Factor (hGRF)1-29-Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats: Identification of CJC-1295 as a Long-Lasting GRF Analog.” Endocrinology 146(7), 2005, 3052–3058. PubMed
• Ionescu, M., and L. A. Frohman. “Pulsatile Secretion of Growth Hormone Persists During Continuous Stimulation by CJC-1295, a Long-Acting GHRH Analog.” Journal of Clinical Endocrinology & Metabolism 91(12), 2006, 4792–4797. PubMed
• Teichman, S. L., et al. “Prolonged Stimulation of GH and IGF-I Secretion by CJC-1295, a Long-Acting Analog of GHRH, in Healthy Adults.” Journal of Clinical Endocrinology & Metabolism 91(3), 2006, 799–805. PubMed
• Sackmann-Sala, L., Ding, J., Frohman, L. A., Kopchick, J. J. “Activation of the GH/IGF-1 Axis by CJC-1295, a Long-Acting GHRH Analog, Results in Serum Protein Profile Changes in Normal Adult Subjects.” Growth Hormone & IGF Research 19(6), 2009, 471–477. PubMed
• Alba, M., et al. “Once-Daily Administration of CJC-1295, a Long-Acting GHRH Analog, Normalizes Growth in the GHRH Knockout Mouse.” American Journal of Physiology – Endocrinology and Metabolism 291(6), 2006, E1290–E1294. PubMed
• Memdouh, S., Gavrilović, I., Ng, K., Cowan, D., Abbate, V. “Advances in the Detection of Growth Hormone Releasing Hormone Synthetic Analogs.” Drug Testing & Analysis 13(11–12), 2021, 1871–1887. PubMed
• Coppieters, G., Deventer, K., Polet, M., Van Eenoo, P., Judák, P. “An Antibody-Free, Ultrafiltration-Based Assay for the Detection of Growth Hormone-Releasing Hormones in Urine at Low pg/mL Concentrations Using NanoLC-HRMS/MS.” Journal of Pharmaceutical and Biomedical Analysis 214, 2022, 114726. PubMed

Compliance & RUO Disclaimer

For laboratory research use only (RUO). Not for human or veterinary use, ingestion, diagnostic, or therapeutic applications. Purchase and use are limited to qualified personnel operating under institutional laboratory guidelines.