DSIP 2mg

DSIP (Delta Sleep-Inducing Peptide) 2 mg is a rigorously characterized nonapeptide (sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) supplied by Peptide Tech at ≥ 99% purity (HPLC/MS verified) for in-vitro, cellular, and biochemical research use only (RUO). DSIP is commonly used to probe neuromodulatory pathways, epithelial transport, and controlled-release formulations under standardized laboratory conditions.

 

Specifications

CAS Number	62568-57-4
Chemical Name	Delta Sleep-Inducing Peptide (DSIP); synonym: Emideltide
PubChem CID	Base peptide: CID 68816  |  Phosphate: CID 172600
Molecular Formula (base)	C35H48N10O15
Molecular Weight	Base: ~848.8 g/mol  |  Phosphate salt: ~928.8 g/mol
Sequence	Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Physical Appearance	White to off-white lyophilized powder
Container	3 mL glass vial (2 mg net content)
Purity	≥ 99% (verified by HPLC & MS; third-party confirmation)
Solubility	Soluble in sterile water or compatible aqueous buffer (e.g., PBS). Gently mix until fully dissolved; filter-sterilize (0.22 µm) if required.

Molecular Structure

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Storage & Handling

• Lyophilized (unopened): Store at ≤ −20 °C, protected from light and moisture. For long-term archival, ≤ −80 °C is recommended.
• After reconstitution: Aliquot to avoid repeated freeze–thaw. Store at ≤ −80 °C for maximal stability (≤ −20 °C acceptable for short-term studies).
• Buffer notes: Use sterile water or compatible buffer (e.g., PBS). Avoid strong acids/bases and repeated temperature cycling.
• Research Use Only (RUO): Not for human or animal administration, diagnostic, or therapeutic use.

Potential Applications in Research

Strictly in-vitro, cellular, or biochemical contexts — no clinical or human-use claims.

• Opioid peptide signaling (in vitro): DSIP has been used to evoke calcium-dependent release of Met-enkephalin from rodent brain slices/synaptosomes for pathway mapping.
  Brain Research, 1989;
  J. Neurochem., 1991.
• Pineal enzyme assays & adrenergic modulation: Studies of rat pineal N-acetyltransferase activity implicate α₁-adrenergic involvement.
  J. Neurochem., 1987.
• Glutamatergic mechanisms (electrophysiology): DSIP effects on neuronal firing explored via microiontophoresis; NMDA receptor participation suggested.
  Pathophysiology, 2004.
• Peptide transport & metabolism (Caco-2): Quantify DSIP transport dynamics and stability in intestinal epithelial monolayers.
  Drug Metab. Dispos., 1996.
• Controlled-release formulations: Use DSIP as a model payload for in-vitro release profiling from polymeric hydrogels.
  Biochemistry (Moscow) Suppl. B, 2012.

Citations

1. Nakamura, A., et al. “Delta-sleep-inducing peptide (DSIP) stimulates the release of immunoreactive Met-enkephalin from rat lower brainstem slices in vitro.” Brain Research, 1989.
   Link
2. Nakamura, A., K. Sakai, Y. Takahashi, and H. Shiomi. “Characterization of DSIP-evoked release of Met-enkephalin from brain synaptosomes in rats.” Journal of Neurochemistry, 57(3), 1991, pp. 1013–1018.
   PMID: 1861139
3. Graf, M. V., and G. A. Schoenenberger. “Delta Sleep-Inducing Peptide modulates the stimulation of rat pineal N-acetyltransferase activity by an α₁-adrenergic receptor mechanism.” Journal of Neurochemistry, 48(4), 1987, pp. 1252–1257.
   PMID: 3029331
4. Sudakova, K. V., P. E. Umriukhina, and K. S. Rayevsky. “Delta-sleep-inducing peptide and neuronal activity after glutamate microiontophoresis: the role of NMDA-receptors.” Pathophysiology, 11(2), 2004, pp. 81–86.
   Link
5. Augustijns, P., and R. T. Borchardt. “Transport and metabolism of delta-sleep-inducing peptide in cultured human intestinal epithelial (Caco-2) cell monolayers.” Drug Metabolism and Disposition, 1996.
   PMID: 8689946
6. Monnier, M., et al. “The delta sleep-inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide.” Experientia, 33(4), 1977, pp. 548–552.
   Link

Compliance & RUO Disclaimer

For laboratory research use only (RUO). Not for human or veterinary use, ingestion, diagnostic, or therapeutic applications. Purchase and use are limited to qualified personnel operating under institutional laboratory guidelines.