Name: 5-Amino-1MQ 10mg - Template
Price: 39.95 USD
Availability: InStock

5-Amino-1MQ 10 mg (5-amino-1-methylquinolinium; NNMTi) from Peptide Tech is a premium, lyophilized research-use-only (RUO) small molecule provided at ≥99% purity (HPLC & MS verified). This methylquinolinium derivative is supplied with full batch traceability and cold-chain logistics for reproducible in-vitro enzymology, metabolism, and cell-biology workflows that require identity confirmation and consistent performance.

Specifications

Property	Details
Product	5-Amino-1MQ — lyophilized powder, 10 mg
Chemical Name	5-amino-1-methylquinolinium (commonly supplied as the iodide salt)
Synonyms	5-Amino-1-methylquinolinium; 1-methylquinolin-1-ium-5-amine; NNMTi; 5-Amino-1-MQ
CAS Number	42464-96-0 (iodide salt)
PubChem CID	950107 (quinolinium cation)
Molecular Formula	C₁₀H₁₁N₂⁺ (cation); iodide salt: C₁₀H₁₁IN₂
Molecular Weight	≈ 159.21 g/mol (cation); iodide salt ≈ 286.11 g/mol
Appearance	Off-white to light tan crystalline powder (color may vary by lot)
Container	3 mL Type I glass vial; butyl stopper; flip-off seal
Purity / Identity	≥99% by HPLC; identity by MS (batch COA via on-vial QR)
Counter-ion	Typically iodide (verify on lot COA)
Solubility	Soluble in DMSO (prepare concentrated stocks); limited aqueous solubility—if needed, co-solvent approach or pH-adjusted buffers per SOP.
Storage (solid)	−20 °C long-term; store desiccated and protected from light.
After Reconstitution	Aliquot and store at ≤ −20 °C; avoid repeat freeze–thaw cycles; use amber vials to limit light exposure.
Intended Use	RUO only. Not for human or animal use.

Molecular Structure

5-Amino-1-methylquinolinium (5-Amino-1MQ) 2D structure — PubChem CID 950107 — View on PubChem (CID 950107)

Key Features of Peptide Tech

Same-Day Shipping (Mon–Fri, on in-stock items)
GMP-Aligned documentation & lyophilization
USA-Made research compounds
24/7 Support & Price Match Guarantee
On-Vial QR for instant COA & chain-of-custody verification
3rd-Party U.S. Lab Testing — purity, quantity, endotoxin
Cold-Chain Shipping — Always (no paid upgrade)
Worldwide Shipping; all major payments accepted
Text & Email order updates; 2-Day FedEx/UPS standard with low-cost overnight
Largest Variety of peptides, small molecules & bioregulators

Potential Applications in Research (RUO)

Strictly for laboratory research. No health, diagnostic, or therapeutic claims.

NNMT enzyme assays — quantify inhibition vs. human NNMT (IC₅₀/K_i) using SAM/NAM turnover and LC–MS or coupled spectrophotometric readouts; compare substrate-site vs. allosteric inhibitors under matched ionic strength.
Cellular NAD⁺ salvage studies — measure intracellular NAD⁺/NADH pools and 1-methylnicotinamide (1-MNA) output in adipocyte, hepatocyte, or fibroblast models after defined dosing; pair with NAMPT pathway gene/protein panels.
Myoblast differentiation models — evaluate C2C12 differentiation markers (e.g., MHC staining), fusion index, and mitochondrial respiration following NNMT inhibition in serum-controlled media.
Epigenetic/metabolism crosstalk — profile histone H3 methylation (e.g., H3K4me) and methionine/SAM cycle metabolites (LC–MS) to study “methylation-sink” mechanisms in cell lines of interest.
Analytical method development — create stability-indicating RP-HPLC or LC–MS(/MS) methods for identity/purity, salt-content verification (iodide), and forced-degradation (light, pH, temperature).

Citations (selected)

Kraus, D., et al. “Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity by augmenting energy expenditure.” Nature (2014). PDF
Ulanovskaya, O. A., et al. “NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink.” Nature Chemical Biology (2013). PDF
“Small molecule NNMT inhibitor activates muscle stem cells and improves regenerative capacity.” Biochemical Pharmacology (2019). Abstract
Review: “Exploring NNMT: from metabolic pathways to therapeutic targets.” Archives of Pharmacal Research (2024). Link

Quality, Storage & Handling

Every lot is confirmed by HPLC (purity) and MS (identity); the on-vial QR links to the batch COA. Independent U.S. labs verify purity, quantity, and endotoxin.

Storage (solid): −20 °C long-term or 2–8 °C short-term; keep desiccated and protected from light.
Reconstitution tips: Prepare concentrated DMSO stocks; for aqueous work, dilute into buffer with gentle mixing. If sterility is required, 0.22 µm filter and aliquot promptly.
Handling: Use calibrated microbalances and solvent-compatible plastics/glass; minimize light and moisture exposure during weighing and transfer.

Shipping & Fulfillment

Ships with validated cold-chain packaging. In-stock orders placed before the daily cutoff ship the same day. 2-Day FedEx/UPS is standard, with overnight options available. Automated text/email updates included; international shipping available where permitted.

Compliance & RUO Disclaimer

For laboratory research only. Not a drug, cosmetic, food, or household chemical. Not for human or animal use, ingestion, diagnostic, or therapeutic applications. Purchasers warrant appropriate qualifications and compliance with applicable regulations and institutional policies.

FAQs

Is this the free base or a salt?: We typically supply the iodide salt for solubility and handling; the cation entry is PubChem CID 950107. Verify the counter-ion on your lot COA.
What solubility should I expect?: 5-Amino-1MQ is readily soluble in DMSO for stock solutions; aqueous solubility is limited and may require co-solvent or pH-adjustment per your SOP.
What purity do you provide?: Each 10 mg vial is ≥99% by HPLC with MS identity confirmation; third-party testing is performed on every lot (COA via on-vial QR).