$89.95
Follistatin-344 (FS-344) — 1 mg from Peptide Tech is a recombinant, lyophilized research-use-only (RUO) glycoprotein supplied with batch-level traceability and third-party testing. Derived from the human FST gene product (344-aa precursor), this material is engineered for in-vitro studies of TGF-β superfamily biology (e.g., activin/myostatin systems), binding/neutralization assays, and protein analytics where sequence fidelity, documentation, and cold-chain integrity are critical.
Specifications
| Property | Details |
|---|---|
| Protein Name | Follistatin (FS-344 precursor; human) |
| Gene / UniProt | FST / P19883 |
| Length / Construct | 344 aa precursor; supplied construct and any tags are lot-specific (commonly aa 30–344). See COA/label. |
| Molecular Weight | ~38 kDa polypeptide (unglycosylated); apparent 36–44 kDa with glycosylation (lot-dependent; see COA). |
| Glycosylation | Yes (glycoprotein). Expression system and glycoform reported on the COA. |
| Appearance | White to off-white lyophilized protein |
| Content per Vial | 1 mg |
| Container | 3 mL Type I glass vial with butyl stopper & flip-off seal |
| Purity / Identity | ≥ 98% by SDS-PAGE/RP-HPLC; identity by MS/Western (batch COA via on-vial QR) |
| Buffer / Excipients | Lot-specific lyoprotectants (see COA) |
| Solubility | Reconstitute in sterile water or PBS; for working stocks use carrier (e.g., 0.1% BSA) per SOP to minimize adsorption. |
| Intended Use | Laboratory research only (RUO). Not for human or animal use. |
Molecular Structure
Follistatin is a multi-domain glycoprotein comprising three follistatin-like domains (FSD1–FSD3) and a C-terminal region; small-molecule 2D depictions are not applicable. Explore domain architecture and models here:
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Potential Applications in Research (RUO)
Strictly for in-vitro, cell-based, or biochemical experiments. No health, diagnostic, or therapeutic claims.
- Ligand binding & neutralization assays with activins/myostatin/BMPs using SPR/BLI or ELISA readouts.
- SMAD reporter workflows (e.g., SMAD2/3 luciferase) to quantify pathway modulation under defined ligand challenge.
- Co-culture and differentiation models (myogenic or stromal cell lines) to map phenotype-linked transcriptional changes in vitro.
- Protein analytics — SDS-PAGE/WB, SEC-MALS, and LC–MS stability/recovery studies across buffers and temperatures.
- Comparative bioassays versus FST isoforms (FS-315/FS-288) to profile domain contributions and potency rank-order.
Quality, Storage & Handling
Each lot includes a QR-linked COA and independent U.S. lab verification of purity, quantity, and endotoxin. Use aseptic technique throughout.
- Storage (lyophilized): −20 °C long-term or 2–8 °C short-term; protect from light and moisture.
- After reconstitution: Aliquot and store at ≤ −20 °C (or −80 °C per SOP); avoid repeated freeze–thaw.
- Buffers & carriers: For working solutions, include inert protein carrier (e.g., 0.1% BSA) to minimize surface loss; verify compatibility with your assay.
Shipping & Fulfillment
Ships in validated cold-chain packaging. In-stock orders placed before the daily cutoff ship the same day. 2-Day FedEx/UPS is standard, with overnight options available. Automated text/email updates included; international shipping available where permitted.
Compliance & RUO Disclaimer
For laboratory research only. Not a drug, cosmetic, food, or household chemical. Not for human or animal use, ingestion, diagnostic, or therapeutic applications. Buyers warrant they are qualified to handle RUO materials under applicable laws and institutional guidelines. COAs available via QR or upon request.
FAQs
- Is this the 344-aa protein or the 30–344 mature region?
- Our FS-344 is produced from the human FST sequence; the supplied region and any fusion tags are listed on the lot COA (commonly aa 30–344 for mature domain coverage).
- What purity do you provide?
- Each 1 mg vial is ≥ 98% by SDS-PAGE/RP-HPLC with MS/Western identity confirmation; third-party testing is performed on every lot (COA via on-vial QR).
- How should I reconstitute and store it?
- Use sterile water or PBS. For working stocks, include 0.1% BSA or another approved carrier, aliquot, and store frozen to avoid repeat freeze–thaw.
- Which in-vitro assays are typical?
- Common RUO applications include activin/myostatin neutralization assays, SMAD reporter readouts, protein binding kinetics by SPR/BLI, and SDS-PAGE/LC–MS stability panels.
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