Ipamorelin 5mg

Specifications

Molecular Structure

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Storage & Handling

• Lyophilized (unopened): Store at ≤ −20 °C, desiccated and protected from light. For long-term archival, ≤ −80 °C is recommended.
• After reconstitution: Aliquot into sterile, low-binding tubes; store at ≤ −80 °C. Avoid repeated freeze–thaw cycles.
• Handling: Allow vial to reach room temperature before opening to minimize condensation. Use sterile technique and neutral pH buffers; add carrier protein (e.g., 0.1% BSA) if adsorption is a concern.
• Research Use Only (RUO): Not for human or veterinary use, ingestion, diagnostic, or therapeutic applications.

Potential Applications in Research

Strictly in-vitro, cellular, or biochemical contexts — no clinical or human-use claims.

• GHS-R1a receptor pharmacology: Quantify potency/efficacy in pituitary or heterologous cell systems using Ca²⁺ mobilization and downstream readouts (e.g., ERK).
  Raun et al., 1998.
• Selectivity profiling vs. other endocrine axes: Compare GH-secretagogue activity with minimal off-target effects in vitro (e.g., ACTH/cortisol pathways) to benchmark assay specificity.
  Raun et al., 1998.
• Receptor trafficking & desensitization: Study GHS-R internalization/β-arrestin recruitment and recovery kinetics in cell-based models.
  Howard et al., 1996.
• Analytical method development: Build LC-MS/MS stability and quantitation methods for peptide exposure and in-matrix recovery; use exposure-response datasets to inform PK/PD modeling frameworks.
  Gobburu et al., 1999.
• Gastrointestinal smooth-muscle pathway assays (ex vivo): Explore ghrelin-receptor–mediated effects on contractility in isolated tissue preparations under controlled conditions.
  Greenwood-Van Meerveld et al., 2012.

Citations (PubMed)

• Howard, A.D., et al. “A receptor in pituitary and hypothalamus that functions in growth hormone release.” Science, 1996;273(5277):974-977.
  PMID: 8688086
• Raun, K., et al. “Ipamorelin, the first selective growth hormone secretagogue.” European Journal of Endocrinology, 1998;139(5):552-561.
  PMID: 9849822
• Gobburu, J.V.S., Agersø, H., Jusko, W.J., Ynddal, L. “Pharmacokinetic–pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers.” Pharmaceutical Research, 1999;16(9):1412-1416.
  PMID: 10496658
• Greenwood-Van Meerveld, B., Tyler, K., Mohammadi, E., Pietra, C. “Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus.” Journal of Experimental Pharmacology, 2012;4:149-155.
  PMID: 27186127

Compliance & RUO Disclaimer

For laboratory research use only (RUO). Not a drug, food, or cosmetic. Not for human or veterinary use. Purchase and use are limited to qualified personnel operating under institutional laboratory guidelines.