Kisspeptin-10 5mg

Kisspeptin-10 (Metastin 45–54) — 5 mg is a decapeptide agonist of the KISS1R (GPR54) receptor, supplied by Peptide Tech at ≥ 99% purity (HPLC/MS verified) for in-vitro, cellular, and biochemical research use only (RUO). In controlled models, Kp-10 is used to interrogate GPCR signaling, GnRH-neuron excitability, and Ca²⁺ dynamics.

 

Specifications

Chemical Name	Kisspeptin-10 (human), Metastin 45–54
Sequence	H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (YNWNSFGLRF-NH2)
CAS Number	374675-21-5
PubChem CID	CID 25240297
Molecular Formula	C63H83N17O14
Molecular Weight (avg.)	≈ 1302.45 g/mol
Monoisotopic Mass	≈ 1301.63 Da
Physical Appearance	White to off-white lyophilized powder
Container	3 mL Type I glass vial (5 mg net content)
Purity	≥ 99% (verified by HPLC & MS; 3rd-party tested)
Solubility	Soluble in sterile water or compatible buffer; if needed, pre-wet with ≤0.1% acetic acid or minimal DMSO, then bring to final buffer. 0.22 µm filter-sterilize if required.

Molecular Structure

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Storage & Handling

• Lyophilized (unopened): Store at ≤ −20 °C, desiccated and protected from light. For long-term archival, ≤ −80 °C is recommended.
• After reconstitution: Aliquot into sterile, low-binding tubes; store at ≤ −80 °C. Avoid repeated freeze–thaw cycles.
• Handling: Allow vial to reach room temperature before opening to minimize condensation. Use sterile technique and neutral pH buffers; add carrier protein (e.g., 0.1% BSA) if adsorption is a concern.
• Research Use Only (RUO): Not for human or veterinary use, ingestion, diagnostic, or therapeutic applications.

Potential Applications in Research

Strictly in-vitro, cellular, or biochemical contexts — no clinical or human-use claims.

• KISS1R (GPR54) GPCR signaling: Quantify PLC/IP₃-dependent Ca²⁺ mobilization and ERK responses in neuronal/heterologous systems.
  Endocrinology, 2008.
• Ion-channel mechanisms in GnRH neurons: Probe TRPC-like cation currents and modulation of inwardly rectifying K⁺ channels during depolarization.
  J Neurosci, 2008.
• Electrophysiology & excitability mapping: Characterize developmental differences in GnRH neuron responsiveness and firing after Kp-10 exposure.
  J Neurosci, 2005.
• Synaptic input studies (brain slices): Assess estradiol-dependent changes in GABAergic and glutamatergic transmission to GnRH neurons.
  Endocrinology, 2010.

Citations (PubMed)

• Han, S.-K., et al. “Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty.” Journal of Neuroscience, 2005.
  PMID: 16339030
• Zhang, C., et al. “Kisspeptin Depolarizes Gonadotropin-Releasing Hormone Neurons through Activation of TRPC-Like Cationic Channels.” Journal of Neuroscience, 2008.
  PMID: 18434521
• Liu, X., Lee, K., Herbison, A. E. “Kisspeptin Excites Gonadotropin-Releasing Hormone Neurons through a Phospholipase C/Calcium-Dependent Pathway Regulating Multiple Ion Channels.” Endocrinology, 2008.
  PMID: 18483150
• Pielecka-Fortuna, J., Moenter, S. M. “Kisspeptin Increases γ-Aminobutyric Acidergic and Glutamatergic Transmission Directly to GnRH Neurons in an Estradiol-Dependent Manner.” Endocrinology, 2010.
  PMID: 19880809

Compliance & RUO Disclaimer

For laboratory research use only (RUO). Not a drug, food, or cosmetic. Not for human or veterinary use. Purchase and use are limited to qualified personnel operating under institutional laboratory guidelines.