Cagrilintide — 10 mg (3 mL vial, lyophilized peptide)

Cagrilintide (AM833) — a long-acting, acylated amylin analog that engages nonselective amylin receptors (AMYR) and calcitonin receptors (CTR) in in-vitro GPCR pharmacology. The N-terminus is lipidated via an eicosanedioic-acid–γ-Glu linker to Lys, enhancing albumin association and peptide persistence in cell-based systems. Supplied by Peptide Tech at ≥ 99% purity (HPLC/MS verified) for in-vitro, cellular, and biochemical research use only (RUO). Not for human or veterinary use.

Specifications

CAS Number	1415456-99-3
Chemical Name	Acylated amylin analog (AM833; “cagrilintide”)
PubChem CID	167312356
Molecular Formula	C₁₉₄H₃₁₂N₅₄O₅₉S₂
Molecular Weight	~4,409 Da
Sequence	{Eicosanedioic acid-γ-Glu}-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Pro-NH₂ (disulfide: Cys3–Cys8)
Counter-ion	Acetate (confirm on lot COA)
Physical Appearance	White to off-white lyophilized powder
Container	3 mL Type I glass vial, bromobutyl rubber stopper, aluminum flip-off seal (net content: 10 mg)
Purity	≥ 99% (verified by HPLC & MS; third-party tested)
Solubility	Soluble in sterile water; for concentrated stocks, pre-wet with ≤0.1% acetic acid and gently agitate. High-concentration stocks (≈ ≥50 mg/mL) have been reported with ultrasonication and mild warming; 0.22 µm filter-sterilize if required.

Molecular Structure (Reference)

Molecular structure of Cagrilintide

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Storage & Handling

Lyophilized (unopened): Store at ≤ −20 °C, protected from light and moisture. For long-term archival, ≤ −80 °C is recommended.
After reconstitution: Aliquot into sterile, low-binding tubes; store at ≤ −80 °C. Avoid repeated freeze–thaw cycles.
Handling: Allow vial to reach room temperature before opening to minimize condensation. Use sterile technique and compatible, neutral-pH buffers; consider carrier protein to mitigate adsorption.
Research Use Only (RUO): Not for human or veterinary use, ingestion, diagnostic, or therapeutic applications.

Potential Applications in Research

Strictly in-vitro, cellular, or biochemical contexts — no clinical or human-use claims.

AMYR/CTR pharmacology: cAMP accumulation, β-arrestin recruitment, and pathway-bias profiling in engineered receptor systems.
Ligand binding/occupancy: Receptor competition and kinetics vs. amylin and analog comparators.
Structure–function studies: Evaluate effects of lipidation and disulfide constraints on receptor engagement and trafficking.
Receptor cross-talk: Explore AMYR/CTR signaling interactions with GLP-1R pathways in co-expression models.
Stability & formulation research: Assess aggregation resistance, adsorption, and excipient impacts under cell-culture conditions.

Citations (PubMed)

Kruse, T., et al. “Development of Cagrilintide, a Long-Acting Amylin Analogue.” J Med Chem, 2021. PubMed
Lau, D. C. W., et al. “Once-weekly cagrilintide for weight management: phase 2 trial.” The Lancet, 2021. PubMed
D’Ascanio, A. M., et al. “A Long-Acting Amylin Analog for the Treatment of Obesity.” Obes Surg, 2024. PubMed

Compliance & RUO Disclaimer

For laboratory research use only (RUO). Not a drug, food, or cosmetic. Not for human or veterinary use. Purchase and use are limited to qualified personnel operating under institutional laboratory guidelines.