$39.95
GHK-Cu (Copper Tripeptide) 100 mg is the copper(II) complex of the tripeptide Gly-His-Lys, supplied by Peptide Tech at ≥ 99% purity (HPLC/MS verified) for in-vitro, cellular, and biochemical research use only (RUO). GHK-Cu is widely used in dermal fibroblast and extracellular-matrix (ECM) models to explore collagen regulation, glycosaminoglycan/proteoglycan biology, and matrix-remodeling enzymes under controlled laboratory conditions.
Specifications
| Property | Details |
|---|---|
| CAS Number | 89030-95-5 (GHK-Cu complex) |
| Chemical Name | Glycyl-L-histidyl-L-lysine, copper(II) complex (GHK-Cu) |
| PubChem CID | CID 378611 (complex) |
| Molecular Formula (complex) | C14H22CuN6O4 (may vary by counter-ion/salt form) |
| Molecular Weight (complex) | ≈ 402 g/mol (approx.; varies by counter-ion/salt form) |
| Sequence | Gly-His-Lys (Cu2+ coordinated) |
| Physical Appearance | Blue to blue-green lyophilized powder |
| Container | 3 mL glass vial (100 mg net content) |
| Purity | ≥ 99% verified by HPLC & MS |
| Solubility | Freely soluble in sterile water or compatible aqueous buffer; mix gently until fully dissolved; filter-sterilize (0.22 µm) if required |
Molecular Structure
Storage & Handling
Lyophilized (unopened): Store at ≤ −20 °C in a dry, dark environment. For short-term staging, 2–8 °C is acceptable if the vial remains sealed.
After reconstitution: Prepare sterile aliquots; store at ≤ −20 °C (≤ −80 °C recommended for extended periods). Avoid repeated freeze–thaw cycles.
Let vial equilibrate to room temperature before opening to minimize condensation; mix by gentle inversion—avoid aggressive vortexing.
Potential Applications in Research
Strictly in-vitro, cellular, or biochemical contexts — no clinical or human-use claims.
- Dermal fibroblast ECM assays: Quantify collagen production and related markers in cultured fibroblasts across sub-nanomolar to nanomolar ranges.
Foundational studies reported stimulation of collagen synthesis by GHK-Cu in fibroblast cultures.
Maquart et al., 1988. - MMP/TIMP pathway studies: Examine modulation of matrix metalloproteinase-2 (gelatinase A) expression in fibroblast culture, with complementary TIMP measurements.
Siméon et al., 2000. - Glycosaminoglycan/proteoglycan profiling: Measure GAG and small proteoglycan expression in dermal fibroblasts to study matrix deposition pathways.
Siméon et al., 2000. - Coordination chemistry & analytical controls: Use the defined Cu(II)–ligand coordination of GHK for method development (e.g., LC–MS/HPLC identity, stability, and copper-binding studies) with PubChem CID as the structural reference.
PubChem.
Citations
- Maquart, François-Xavier, et al. “Stimulation of Collagen Synthesis in Fibroblast Cultures by the Tripeptide–Copper Complex Glycyl-L-Histidyl-L-Lysine-Cu2+.”
FEBS Letters, vol. 238, no. 2, 1988, pp. 343–346.
PDF - Siméon, Alain, et al. “The Tripeptide–Copper Complex Glycyl-L-Histidyl-L-Lysine-Cu2+ Stimulates Matrix Metalloproteinase-2 Expression by Fibroblast Cultures.”
Life Sciences, vol. 67, no. 18, 2000, pp. 2257–2265.
Journal page - Siméon, Alain, et al. “Expression of Glycosaminoglycans and Small Proteoglycans in Wounds: Modulation by the Tripeptide–Copper Complex Glycyl-L-Histidyl-L-Lysine-Cu2+.”
Journal of Investigative Dermatology, vol. 115, no. 6, 2000, pp. 962–968.
Europe PMC - “PubChem Compound Summary for CID 378611: Glycyl-L-histidyl-L-lysine Copper(II) Complex.” PubChem.
Entry
Compliance & RUO Disclaimer
For laboratory research use only (RUO). Not for human or veterinary use, ingestion, diagnostic, or therapeutic applications.
Purchase and use are limited to qualified personnel operating under institutional laboratory guidelines.
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