MTII 10 mg (Melanotan II; MT-2) from Peptide Tech is a premium, lyophilized research-use-only (RUO) peptide supplied at ≥99% purity (HPLC & MS verified). MTII is a cyclic heptapeptide analog of α-MSH with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ (lactam bridge between Asp and Lys). It’s widely used in in-vitro melanocortin receptor studies, cAMP signaling assays, and ligand-binding workflows where sequence fidelity and analytical traceability are essential.

Specifications

Property	Details
CAS Number	121062-08-6
Chemical Name	Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ (Melanotan II; MT-2)
PubChem CID	92432
Molecular Formula	C₅₀H₆₉N₁₅O₉
Molecular Weight	≈ 1024.18 g/mol
Physical Appearance	White to off-white lyophilized powder
Sequence	Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ (cyclic 2→7)
Container	3 mL glass vial (10 mg net content)
Purity	≥99% verified by HPLC & MS (lot COA via QR)
Solubility	Soluble in sterile water or compatible aqueous buffer; gentle agitation/brief sonication may aid dissolution. Optimize pH/ionic strength for your assay; filter-sterilize if required.
Intended Use	Laboratory research only (RUO). Not for human or animal use.

Identifiers validated against NIH GSRS and Sigma listings; structure/identifier link via PubChem CID above.

Molecular Structure

Key Features of Peptide Tech

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Potential Applications in Research

Strictly in-vitro, cellular, or biochemical contexts. No health, diagnostic, or therapeutic claims.

Melanocortin receptor signaling (MC1R/MC3R/MC4R) using cAMP reporter assays, CRE-luciferase, or HTRF/cAMP kits in stable cell lines.
β-arrestin recruitment & receptor internalization (BRET/ELISA/confocal) to study trafficking and biased signaling profiles.
Radioligand or competition binding in membrane preparations to quantify affinity/kinetics and rank-order potency versus related analogs.
Melanogenesis pathway readouts in vitro (e.g., tyrosinase activity, melanin content) in melanocyte cultures under controlled conditions.
Analytical method development (RP-HPLC/LC–MS/MS) for identity, stability, and recovery in relevant matrices.

Quality, Storage & Handling

Every lot is confirmed by HPLC (purity) and MS (identity), with QR-linked batch documentation. Independent U.S. labs verify purity, quantity, and endotoxin.

Storage (lyophilized): −20 °C long term or 2–8 °C short term; keep desiccated and protected from light.
After reconstitution: Aliquot and store at ≤−20 °C (or −80 °C per SOP); avoid repeated freeze–thaw cycles.
Reconstitution tips: Use sterile water or suitable buffer; gently invert to dissolve; filter-sterilize only if required by your assay.

Shipping & Fulfillment

Ships in validated cold-chain packaging. In-stock orders placed before the daily cutoff ship the same day. 2-Day FedEx/UPS is standard, with overnight options available. Automated text/email updates included; international shipping available where permitted.

Compliance & RUO Disclaimer

For laboratory research only. Not a drug, cosmetic, food, or household chemical. Not for human or animal use, ingestion, diagnostic, or therapeutic applications. Buyers warrant they are qualified to handle RUO materials under applicable laws and institutional guidelines. COAs available upon request or via QR.

FAQs

Is this intended for human or veterinary use?: No. This product is sold strictly as RUO—not for human or animal use.
What purity do you provide?: Each 10 mg vial is ≥99% by HPLC with MS identity confirmation; third-party testing is performed on every lot (see the COA via QR).
How should I reconstitute it?: Use sterile water or a compatible aqueous buffer; gently invert until fully dissolved. If your protocol requires sterility, pass through a 0.22 µm filter and aliquot to avoid repeat freeze–thaw.
Which in-vitro assays is MTII commonly used in?: Typical RUO applications include melanocortin receptor cAMP assays, β-arrestin/internalization workflows, radioligand binding, and LC–MS/MS method development.