Phenibut HCl (Hydrochloride) — 50 g Powder, Research Grade (RUO)

Phenibut HCl (4-amino-3-phenylbutanoic acid hydrochloride) from Peptide Tech is supplied as a white crystalline powder for laboratory research use only. Each sealed jar contains 50 grams of research-grade material with ≥98% purity (HPLC), batch-level traceability, and QR-linked documentation. The hydrochloride salt offers convenient aqueous handling for in-vitro, cell-based, and analytical method development—no human or veterinary use is implied.

Specifications

Molecular Structure

Key Features — Peptide Tech

• Same-Day Shipping (Mon–Fri, on in-stock items)
• GMP-Aligned synthesis & packaging
• USA Made with QR batch tracking
• COA Access — purity/identity per lot
• Third-Party U.S. Lab Testing — purity, quantity; method notes where applicable
• Cold-Chain Shipping — Always (no paid upgrade)
• Worldwide Shipping with compliant documentation
• Text & Email Order Updates; 2-Day FedEx/UPS Standard & economical Overnight options

Potential Applications in Research

Strictly non-clinical. Focus on in-vitro, cellular, and analytical work; avoid any human-use implications.

• GABA_B receptor pharmacology (cell systems) — quantify Gi/o-mediated cAMP inhibition, GIRK activation, or Ca²⁺ channel modulation in recombinant assays using phenibut as a tool ligand.
• α₂δ-subunit interaction studies — evaluate binding to voltage-gated calcium-channel α₂δ proteins and compare to gabapentinoids in biochemical/cell models.
• Analytical method development — develop/validate LC-MS/MS or HPLC-DAD methods (ID, assay, stability/forced-degradation) for aromatic amino-acid analogues in complex matrices.
• Chiral/separation research — examine enantiomer-specific behavior (R/S) via chiral HPLC and differential receptor/α₂δ affinities.
• Solubility & formulation screens — characterize pH-dependent solubility, solvent compatibility, and recovery for downstream in-vitro workflows.

Citations (supports “Potential Applications” only)

• Lapin, I. “Phenibut (β-Phenyl-GABA): A Tranquilizer and Nootropic Drug.” CNS Drug Reviews, 2001/2006. PMC6494145
• Zvejniece, L., et al. “R-Phenibut Binds to the α₂δ Subunit of Voltage-Dependent Calcium Channels.” Pharmacol. Biochem. Behav., 2015, 137:23–29. PubMed 26234470
• Dziadosz, M., et al. “Phenibut Screening and Quantification with LC–MS/MS.” J. Forensic Sci., 2024. PubMed 38146811
• Upmanis, T., et al. “Identification and Quantification of Ingredients in Phenibut-Containing Products.” Molecules, 2024. PMC11509446

Quality, Storage & Handling

• Identity & Purity: Verified by HPLC; additional identity checks available by lot (see COA).
• Storage: Keep sealed, cool, dry, and protected from light. Avoid humid environments; hygroscopic uptake may affect massing.
• Handling: Use appropriate PPE and clean-bench technique. Prepare solutions fresh; confirm solvent/pH compatibility and filter per SOP.

Shipping & Fulfillment

Ships with validated cold-chain packaging. In-stock orders placed before the daily cutoff dispatch the same day. 2-Day FedEx/UPS is standard, with overnight options available. Automated text/email updates included; international service available where permitted.

Compliance & RUO Disclaimer

For laboratory research use only. Not a drug, food, or cosmetic. Not for human consumption, diagnostic, therapeutic, or veterinary use. Purchasers must be qualified to handle RUO materials and comply with applicable laws and institutional policies.

FAQs

Is this the HCl salt or FAA?

This listing is for the hydrochloride salt (HCl). For the free-acid (FAA) form, see the separate RUO product page.

What’s the expected water solubility?

The HCl salt is highly water-soluble relative to the FAA form. Optimize pH/ionic strength for your method and record recovery.

How do I access batch documentation?

Scan the jar’s QR code or contact support for the lot-specific COA and testing summary.