Noopept (Powder) — 10 g, Research Grade (RUO)

Noopept (N-phenylacetyl-L-prolylglycine ethyl ester; also known as Omberacetam, GVS-111) is a small-molecule dipeptide analogue supplied by Peptide Tech for laboratory research use only. Each jar contains 10 grams of white crystalline powder produced under GMP-aligned procedures with ≥99% purity (HPLC & MS verified). Trusted by method developers and cell-biology teams, this analyte is suitable for in-vitro, cell-based, and biochemical workflows where identity, purity, and batch traceability matter.

Specifications

Molecular Structure

Key Features — Peptide Tech

• Same-Day Shipping (Mon–Fri, on in-stock items)
• GMP-Aligned Synthesis & Packaging
• USA Made
• 24/7 Support
• Price Match Guarantee
• Batch-Level Traceability with QR code verification
• 3rd-Party USA Lab Testing — purity, quantity, endotoxin
• Cold-Chain Shipping — Always (no paid upgrade)
• Worldwide Shipping
• All Major Payments Accepted
• Text & Email Order Updates
• 2-Day FedEx/UPS Standard with low-cost Overnight options
• Largest Variety of peptides, peptide analogues & bioregulators (RUO)

Potential Applications in Research

Focus strictly on in-vitro, cellular, biochemical, and analytical contexts. No health claims or human/animal use are implied.

• Cell-based stress pathway readouts — probe HIF-1–linked transcriptional responses with reporter assays (e.g., HEK293 or SH-SY5Y models) under controlled hypoxia-mimetic conditions.
• Neurotoxicity challenge models (in vitro) — evaluate endpoints such as viability, apoptosis markers, ROS, Ca²⁺ flux, and mitochondrial potential in PC12 or neuronal lines after defined stressors.
• Protein aggregation & biophysical assays — examine effects on in-vitro amyloid oligomerization/aggregation (e.g., α-synuclein) with ThT fluorescence, CD, AFM, and complementary cytometry readouts.
• Excitotoxicity paradigms — use glutamate-exposed neuronal cells (e.g., HT-22) to quantify survival/morphology shifts across concentration–time matrices.
• Mechanistic mapping — interrogate selective transcription factor activity (e.g., HIF-1) vs. other TF panels via luciferase reporters to delineate pathway specificity.
• Analytical method development — develop/validate HPLC or LC-MS/MS methods (ID, assay, stability/forced-degradation, polymorph/solid-state profiling) for small-molecule peptide analogues.

Citations

• Ostrovskaya, R. U., et al. “Neuroprotective Effect of Novel Cognitive Enhancer Noopept on AD-Related Cellular Model Involves the Attenuation of Apoptosis and Tau Hyperphosphorylation.” Journal of Biomedical Science, vol. 21, 2014, article 74. https://pmc.ncbi.nlm.nih.gov/articles/PMC4422191/
• Vakhitova, Y. V., et al. “Molecular Mechanism Underlying the Action of Substituted Pro-Gly Dipeptide Noopept.” Acta Naturae, vol. 8, no. 1, 2016, pp. 82–89. https://pmc.ncbi.nlm.nih.gov/articles/PMC4837574/
• Zainullina, L. F., et al. “Cognitive Enhancer Noopept Activates Transcription Factor HIF-1.” Doklady Biochemistry and Biophysics, vol. 494, no. 1, 2020, pp. 256–260. https://pubmed.ncbi.nlm.nih.gov/33119829/
• Antipova, T. A., et al. “Dipeptide Piracetam Analogue Noopept Improves Viability of Hippocampal HT-22 Neurons in the Glutamate Toxicity Model.” Bulletin of Experimental Biology and Medicine, vol. 161, no. 1, 2016, pp. 58–60. https://pubmed.ncbi.nlm.nih.gov/27265136/
• Jia, X., et al. “Neuroprotective and Nootropic Drug Noopept Rescues α-Synuclein Amyloid Cytotoxicity.” Journal of Molecular Biology, vol. 414, no. 5, 2011, pp. 699–712. https://pubmed.ncbi.nlm.nih.gov/21986202/
• Araj, S. K., et al. “Physicochemical and Structural Analysis of N-Phenylacetyl-L-Prolylglycine Ethyl Ester (Noopept) — An Active Pharmaceutical Ingredient with Nootropic Activity.” Journal of Pharmaceutical and Biomedical Analysis, vol. 252, 2025, 116474. https://pubmed.ncbi.nlm.nih.gov/39298839/

Quality, Storage & Handling

Every lot is confirmed by HPLC (purity) and MS (identity), with QR-linked batch documentation. Third-party U.S. labs verify purity, quantity, and endotoxin.

• Storage (powder): Store sealed, dry, protected from light at 2–8 °C (short term) or ≤−20 °C (long term).
• Handling: Use appropriate PPE and clean-bench technique. Prepare fresh analytical standards; filter if required by your method.
• After dissolution: Aliquot and freeze per SOP; avoid repeated freeze–thaw. Validate solvent compatibility for your assay.

Shipping & Fulfillment

Ships with validated cold-chain packaging. In-stock orders placed before the daily cutoff dispatch the same day. 2-Day FedEx/UPS is standard, with overnight options available. Automated text/email order updates included; international service available where permitted.

Compliance & RUO Disclaimer

For laboratory research use only. Not a drug, food, or cosmetic. Not for human or animal use, ingestion, diagnostic, or therapeutic applications. Purchaser warrants they are qualified to handle RUO materials under applicable laws and institutional policies.

FAQs

Is this intended for human consumption?

No. This is a research-use-only material and is not sold for any form of ingestion or therapeutic use.

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What class of compound is Noopept?

Noopept is a small-molecule dipeptide analogue (Pro–Gly motif). It is not a linear peptide chain.

Typical lab uses?

Common applications include in-vitro transcription-factor reporter assays, defined neurotoxicity challenge models, aggregation biophysics, and analytical method development (see citations above).

How do I access the COA?

Scan the QR code on the jar for batch details and downloadable documentation.

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