Piracetam (powder) – 50g

Piracetam — 50 g (powder, glass jar)

2-(2-oxopyrrolidin-1-yl)acetamide (Piracetam) — a prototypical racetam used as a reference small-molecule modulator in in-vitro AMPA-type glutamate receptor studies and in membrane biophysics assays evaluating bilayer fluidity and cell rheology. Supplied by Peptide Tech at ≥ 99% purity (HPLC/MS verified) for in-vitro, cellular, and biochemical research use only (RUO). Not for human or veterinary use.

Specifications

CAS Number	7491-74-9
Chemical Name	2-(2-oxopyrrolidin-1-yl)acetamide (Piracetam)
PubChem CID	4843
Molecular Formula	C6H10N2O2
Molecular Weight	142.16 g/mol
Sequence	N/A (small-molecule; not a peptide)
Physical Appearance	White to off-white crystalline powder
Container	Type I amber glass jar (net content: 50 g)
Purity	≥ 99% (verified by HPLC & MS; third-party tested)
Solubility	Soluble in water (reported stocks up to ~100 mM ≈ 14 mg/mL); soluble in DMSO, methanol, and ethanol. Prepare concentrated stocks, then dilute into final assay buffer; 0.22 µm filter if clarity is required.

Molecular Structure (Reference)

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Storage & Handling

• Solid (unopened): Store sealed at 2–8 °C, protected from light and moisture. For long-term archival, ≤ −20 °C is recommended.
• Solutions: Aliquot aqueous or organic stocks into low-binding tubes; store at ≤ −20 °C. Avoid repeated freeze–thaw cycles.
• Handling: Allow container to equilibrate to room temperature before opening to minimize condensation; reseal promptly.
• Research Use Only (RUO): Not for human or veterinary use, ingestion, diagnostic, or therapeutic applications.

Potential Applications in Research

Strictly in-vitro, cellular, or biochemical contexts — no clinical or human-use claims.

• AMPA receptor modulation: Assess effects on desensitization/deactivation and ligand-binding domain dimer interface dynamics by electrophysiology or structural assays.
• LBD binding-site mapping: Compare occupancy vs. aniracetam/cyclothiazide to explore multiple low-affinity allosteric pockets along the dimer interface.
• Membrane biophysics: Quantify changes in bilayer fluidity (e.g., DPH anisotropy) in neuronal membrane preparations.
• Cell rheology models: Examine red-blood-cell deformability and platelet rheology endpoints in vitro.
• Mitochondrial/function coupling studies: Evaluate effects on mitochondrial dysfunction models and synaptosomal membranes in aged tissue preparations.

Citations (PubMed)

• Ahmed, A. H., & Oswald, R. E. “Piracetam defines a new binding site for allosteric modulators of AMPA receptors.” J Med Chem, 2010. PubMed
• Müller, W. E., et al. “Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain.” Pharmacol Biochem Behav, 1997. PubMed
• Eckert, G. P., et al. “Piracetam reverses hippocampal membrane alterations in Alzheimer’s disease.” Ann N Y Acad Sci, 1999. PubMed
• Gini, E. K., et al. “Use of piracetam improves sickle cell deformability in vitro and in vivo.” Br J Haematol, 1987. PubMed
• Moriau, M., et al. “Platelet anti-aggregant and rheological properties of piracetam.” J Clin Pharmacol, 1993. PubMed

Compliance & RUO Disclaimer

For laboratory research use only (RUO). Not a drug, food, or cosmetic. Not for human or veterinary use. Purchase and use are limited to qualified personnel operating under institutional laboratory guidelines.

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Always read the label and use products as directed. Consult a qualified professional where appropriate.