Piracetam — 50 g (powder, glass jar)

2-(2-oxopyrrolidin-1-yl)acetamide (Piracetam) — a prototypical racetam used as a reference small-molecule modulator in in-vitro AMPA-type glutamate receptor studies and in membrane biophysics assays evaluating bilayer fluidity and cell rheology. Supplied by Peptide Tech at ≥ 99% purity (HPLC/MS verified) for in-vitro, cellular, and biochemical research use only (RUO). Not for human or veterinary use.

Specifications

CAS Number	7491-74-9
Chemical Name	2-(2-oxopyrrolidin-1-yl)acetamide (Piracetam)
PubChem CID	4843
Molecular Formula	C₆H₁₀N₂O₂
Molecular Weight	142.16 g/mol
Sequence	N/A (small-molecule; not a peptide)
Physical Appearance	White to off-white crystalline powder
Container	Type I amber glass jar (net content: 50 g)
Purity	≥ 99% (verified by HPLC & MS; third-party tested)
Solubility	Soluble in water (reported stocks up to ~100 mM ≈ 14 mg/mL); soluble in DMSO, methanol, and ethanol. Prepare concentrated stocks, then dilute into final assay buffer; 0.22 µm filter if clarity is required.

Molecular Structure (Reference)

Molecular structure of Piracetam

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Storage & Handling

Solid (unopened): Store sealed at 2–8 °C, protected from light and moisture. For long-term archival, ≤ −20 °C is recommended.
Solutions: Aliquot aqueous or organic stocks into low-binding tubes; store at ≤ −20 °C. Avoid repeated freeze–thaw cycles.
Handling: Allow container to equilibrate to room temperature before opening to minimize condensation; reseal promptly.
Research Use Only (RUO): Not for human or veterinary use, ingestion, diagnostic, or therapeutic applications.

Potential Applications in Research

Strictly in-vitro, cellular, or biochemical contexts — no clinical or human-use claims.

AMPA receptor modulation: Assess effects on desensitization/deactivation and ligand-binding domain dimer interface dynamics by electrophysiology or structural assays.
LBD binding-site mapping: Compare occupancy vs. aniracetam/cyclothiazide to explore multiple low-affinity allosteric pockets along the dimer interface.
Membrane biophysics: Quantify changes in bilayer fluidity (e.g., DPH anisotropy) in neuronal membrane preparations.
Cell rheology models: Examine red-blood-cell deformability and platelet rheology endpoints in vitro.
Mitochondrial/function coupling studies: Evaluate effects on mitochondrial dysfunction models and synaptosomal membranes in aged tissue preparations.

Citations (PubMed)

Ahmed, A. H., & Oswald, R. E. “Piracetam defines a new binding site for allosteric modulators of AMPA receptors.” J Med Chem, 2010. PubMed
Müller, W. E., et al. “Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain.” Pharmacol Biochem Behav, 1997. PubMed
Eckert, G. P., et al. “Piracetam reverses hippocampal membrane alterations in Alzheimer’s disease.” Ann N Y Acad Sci, 1999. PubMed
Gini, E. K., et al. “Use of piracetam improves sickle cell deformability in vitro and in vivo.” Br J Haematol, 1987. PubMed
Moriau, M., et al. “Platelet anti-aggregant and rheological properties of piracetam.” J Clin Pharmacol, 1993. PubMed

Compliance & RUO Disclaimer

For laboratory research use only (RUO). Not a drug, food, or cosmetic. Not for human or veterinary use. Purchase and use are limited to qualified personnel operating under institutional laboratory guidelines.