Agomelatine (powder) – 1g

Agomelatine — 1 g (powder, glass jar)

N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide (Agomelatine) — a naphthalene acetamide derivative used as a reference ligand for in-vitro melatonin receptor (MT1/MT2) pharmacology and 5-HT_2C antagonist assays. Supplied by Peptide Tech at ≥ 99% purity (HPLC/MS verified) for in-vitro, cellular, and biochemical research use only (RUO). Not for human or veterinary use.

 

Specifications

CAS Number	138112-76-2
Chemical Name	N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide (Agomelatine)
PubChem CID	82148
Molecular Formula	C15H17NO2
Molecular Weight	243.30 g/mol
Sequence	N/A (small-molecule; not a peptide)
Physical Appearance	White to off-white crystalline powder
Container	Type I amber glass jar (net content: 1 g)
Purity	≥ 99% (verified by HPLC & MS; third-party tested)
Solubility	Water: insoluble. DMSO: ≥48–50 mg/mL; Ethanol: up to ~48 mg/mL. For limited aqueous work, ~0.5 mg/mL in 1:1 ethanol:PBS (pH 7.2) has been reported—prepare fresh and do not store >1 day. Prepare concentrated organic stocks, then dilute into assay buffer (<1–2% organic v/v); 0.22 µm filter if clarity is required.

 

Molecular Structure (Reference)

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Storage & Handling

• Solid (unopened): Store sealed at 2–8 °C, protected from light and moisture. For long-term archival, ≤ −20 °C is recommended.
• Solutions: Aliquot DMSO/EtOH stocks into low-binding tubes; store at ≤ −20 °C. Avoid repeated freeze–thaw cycles.
• Handling: Allow container to equilibrate to room temperature before opening to minimize condensation; reseal promptly.
• Research Use Only (RUO): Not for human or veterinary use, ingestion, diagnostic, or therapeutic applications.

 

Potential Applications in Research

Strictly in-vitro, cellular, or biochemical contexts — no clinical or human-use claims.

• MT1/MT2 receptor binding: Displacement of radioligands (e.g., 2-[¹²⁵I]-iodomelatonin) to profile affinity/selectivity vs. melatonin and analogs.
• Gi/o signaling assays: Quantify inhibition of cAMP accumulation and β-arrestin recruitment in MT1/MT2-expressing cells.
• 5-HT_2C functional antagonism: Measure IP₁/Ca²⁺ pathway readouts in 5-HT_2C systems and compare to selective antagonists.
• Circadian reporter models: Evaluate clock-gene (e.g., Per/CRE-luc) phase-shifting/entrainment in cellular systems.
• Pathway cross-talk: Study convergence of melatonergic and serotonergic signaling in co-expression paradigms.
• SAR benchmarking: Use as a reference ligand when profiling racetam/indole/naphthalene analogs at MT1/MT2 and 5-HT_2C.

 

Citations (PubMed)

• Millan, M. J., et al. “The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-HT_2C receptors: blockade of the latter reinforces frontocortical adrenergic and dopaminergic transmission.” Neuropsychopharmacology, 2003. PubMed
• Guardiola-Lemaitre, B., et al. “Agomelatine: mechanism of action and pharmacological profile.” Expert Opin Drug Metab Toxicol, 2014. PubMed / PMC
• Liu, J., et al. “MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective.” J Med Chem, 2016 (review of MT1/MT2 pharmacology; discusses agomelatine). PMC
• Chagraoui, A., et al. “Agomelatine (S 20098) antagonizes 5-HT_2C receptor-mediated responses in vivo.” Psychopharmacology, 2003. PubMed

Compliance & RUO Disclaimer

For laboratory research use only (RUO). Not a drug, food, or cosmetic. Not for human or veterinary use. Purchase and use are limited to qualified personnel operating under institutional laboratory guidelines.