Name: Cortagen 20mg - Template
Price: 49.95 USD
Availability: InStock

Cortagen (Ala-Glu-Asp-Pro; “AEDP”) from Peptide Tech is a lyophilized, ultra-short research peptide manufactured for reproducible in-vitro, cellular, and biochemical studies. With batch-linked COAs and third-party verification, this ≥99% purity tetrapeptide supports rigorous assays exploring gene-expression modulation, neurite biology, oxidative-stress signaling, and peptide–protein interactions under controlled laboratory conditions.

Specifications

Property	Details
Product	Cortagen (AEDP) — 20 mg
Chemical Name	H-Ala-Glu-Asp-Pro-OH
Sequence	Ala-Glu-Asp-Pro (AEDP)
CAS Number	335591-03-2. Reference
Molecular Formula	C₁₇H₂₆N₄O₉
Molecular Weight	~430.41 g/mol (avg); 430.17 Da (monoisotopic). Calculated reference
Appearance	White to off-white lyophilized powder
Content	20 mg per vial
Container	3 mL Type I glass vial, butyl stopper, flip-off seal
Purity / ID	≥99% by HPLC; identity by MS. Lot COA via on-vial QR
Solubility	Water; aqueous buffers (e.g., PBS). For low-µM stocks, consider 0.1% carrier (BSA) to minimize adsorption
Storage (lyo.)	−20 °C (long-term) or 2–8 °C (short-term); protect from light & moisture
After Reconstitution	Aliquot; store ≤−20 °C; avoid repeated freeze-thaw
Intended Use	Research Use Only (RUO). Not for human or animal use

Molecular Structure

Cortagen is a defined tetrapeptide (H-Ala-Glu-Asp-Pro-OH). A canonical PubChem compound page for AEDP is not consistently indexed. For a line-formula/IUPAC representation and calculated properties:

See ChemSpider and supplier monographs:
ChemSpider,
BOC Sciences

Key Features — Peptide Tech

Same-Day Shipping on in-stock items
GMP-Aligned production & documentation
USA-Made lyophilized peptides
24/7 Support & Price Match guarantee
Batch QR for COA / chain-of-custody verification
Certified 3rd-Party U.S. Labs: purity, quantity, endotoxin
Cold-Chain Shipping — Always (no paid upgrade)
Worldwide Shipping; all major payments accepted
Text/Email order updates; 2-Day FedEx/UPS standard & low-cost overnight
Largest Variety of peptides & bioregulators

Potential Applications in Research (RUO)

Strictly for laboratory research. No health, diagnostic, or therapeutic claims are made or implied.

Transcriptome-level modulation assays: Use AEDP in cell or tissue models with cDNA microarray / RNA-seq follow-up to profile differentially expressed genes (e.g., mitochondrial, signaling, stress-response). :contentReference[oaicite:0]{index=0}
Neurite outgrowth & axon biology: Evaluate effects on neurite extension, growth-cone dynamics, or conduction markers in neuron-like cells or ex vivo explants (e.g., DRG), informed by prior sciatic-nerve regeneration studies. :contentReference[oaicite:1]{index=1}
Oxidative-stress & mitochondrial panels: Quantify ROS, ΔΨ_m, and expression of ETC genes (e.g., COX3, ND5) under defined stressors to map AEDP-linked pathways. :contentReference[oaicite:2]{index=2}
Inflammation/cytokine readouts: In glial or mixed neuro-immune co-cultures, measure cytokine profiles and signaling nodes to assess pathway directionality in vitro. :contentReference[oaicite:3]{index=3}
Chromatin/epigenetic screens: Explore chromatin accessibility or heterochromatin marks (e.g., ATAC-seq, H3K9me3 IF) to test short-peptide impacts on nuclear organization suggested for bioregulators. :contentReference[oaicite:4]{index=4}

Citations (MLA)

Anisimov, Sergey V., Vladimir Kh. Khavinson, and Vladimir N. Anisimov. “Elucidation of the Effect of Brain Cortex Tetrapeptide Cortagen on Gene Expression in Mouse Heart by Microarray.” Neuroendocrinology Letters, vol. 25, no. 1–2, 2004, pp. 87–93. PubMed: 15159690. Link. :contentReference[oaicite:5]{index=5}
Turchaninova, A., et al. “Effect of Tetrapeptide Cortagen on Regeneration of Sciatic Nerve.” Neuroscience and Behavioral Physiology, Springer, 2001. Link. :contentReference[oaicite:6]{index=6}
Khavinson, V. Kh., et al. “Epigenetic Regulation of ‘Aged’ Heterochromatin by Short Peptides.” The Protein Journal, 2014. Link. :contentReference[oaicite:7]{index=7}

Quality, Handling & Safety

Verification: Each lot is tested by independent U.S. labs for purity, quantity, and endotoxin; results are accessible via the QR on the vial label.
Reconstitution: Use sterile water or a suitable buffer; for working stocks, include an inert carrier (e.g., 0.1% BSA) when adsorption is a concern.
Aliquoting: Prepare single-use aliquots; avoid freeze–thaw cycles.

Shipping & Fulfillment

Orders ship in validated cold-chain packaging. In-stock vials ship the same business day before cutoff. 2-Day FedEx/UPS is standard; discounted overnight is available. International shipping offered where permitted; automated text/email status updates included.

Compliance & RUO Disclaimer

This material is supplied for laboratory research only. It is not a drug, food, or cosmetic; not for human or animal administration, diagnostic use, or therapeutic use. Purchaser warrants appropriate qualifications and compliance with all applicable regulations and institutional policies.

FAQs

Is Cortagen the same as Cortexin?: No. Cortexin is a heterogeneous protein extract; Cortagen is a defined tetrapeptide (AEDP) synthesized by SPPS and characterized by HPLC/MS. :contentReference[oaicite:8]{index=8}
What documentation comes with each vial?: Every vial is linked to a COA via on-label QR code, including identity (MS), purity (HPLC), quantity, endotoxin, and storage guidance.
How should I design in-vitro work with AEDP?: Start with concentration-response curves in your system, include vehicle controls, and measure pre-specified endpoints (e.g., RNA-seq, ROS, neurite metrics) with appropriate replicates and statistics. See the cited microarray and regeneration literature for model selection. :contentReference[oaicite:9]{index=9}