Aniracetam — 50 g (powder, glass jar)

1-(4-Methoxybenzoyl)pyrrolidin-2-one (Aniracetam) — a pyrrolidinone racetam used widely as a reference positive allosteric modulator (PAM) for AMPA-type ionotropic glutamate receptors in in-vitro electrophysiology and receptor-kinetics research. Supplied by Peptide Tech at ≥ 99% purity (HPLC/MS verified) for in-vitro, cellular, and biochemical research use only (RUO). Not for human or veterinary use.

Specifications

CAS Number	72432-10-1
Chemical Name	1-(4-Methoxybenzoyl)pyrrolidin-2-one (Aniracetam)
PubChem CID	2196
Molecular Formula	C₁₂H₁₃NO₃
Molecular Weight	219.24 g/mol
Sequence	N/A (small-molecule; not a peptide)
Physical Appearance	White to off-white crystalline powder
Container	Type I amber glass jar (net content: 50 g)
Purity	≥ 99% (verified by HPLC & MS; third-party tested)
Solubility	Water: insoluble. DMSO: up to ~44 mg/mL. Ethanol: ~11–18 mg/mL. Prepare concentrated DMSO or ethanol stocks, then dilute into final assay buffer with mixing; filter (0.22 µm) if needed for clarity.

Molecular Structure (Reference)

Molecular structure of Aniracetam

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Storage & Handling

Solid (unopened): Store sealed at 2–8 °C, protected from light and moisture. For long-term archival, ≤ −20 °C is recommended.
Solutions: Aliquot DMSO/EtOH stocks into low-binding tubes; store at ≤ −20 °C. Avoid repeated freeze–thaw cycles.
Handling: Allow container to equilibrate to room temperature before opening to minimize condensation. Reseal promptly; consider inert-gas backfill if frequently accessed.
Research Use Only (RUO): Not for human or veterinary use, ingestion, diagnostic, or therapeutic applications.

Potential Applications in Research

Strictly in-vitro, cellular, or biochemical contexts — no clinical or human-use claims.

AMPA receptor pharmacology: quantify PAM-dependent effects on deactivation and desensitization by whole-cell or outside-out patch clamp.
Receptor isoform studies: compare flip/flop splice variants and site-directed mutants for sensitivity to racetam-class modulators.
Synaptic physiology: examine effects on fast excitatory postsynaptic current (EPSC) decay and short-term plasticity in neurons or brain slices.
Ligand benchmarking: use as a reference modulator alongside cyclothiazide, CX-series, and other AMPAR PAMs.
Structure–activity relationship (SAR): evaluate racetam/ampakine analog panels against AMPAR gating kinetics.
Computational docking/modeling of AMPAR ligand-binding domain (LBD) interfaces with PAMs.

Citations (PubMed)

Isaacson, J. S., & Nicoll, R. A. “Aniracetam reduces glutamate receptor desensitization and slows the decay of fast excitatory synaptic currents in the hippocampus.” Proc Natl Acad Sci USA, 1991. PubMed
Partin, K. M., Fleck, M. W., & Mayer, M. L. “AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate.” J Neurosci, 1996. PubMed
Lawrence, J. J., Brenowitz, S., & Trussell, L. O. “The mechanism of action of aniracetam at synaptic AMPA receptors: indirect and direct effects on desensitization.” Mol Pharmacol, 2003. PubMed
Jin, R., et al. “Mechanism of positive allosteric modulators acting on AMPA receptors.” Proc Natl Acad Sci USA, 2005. PMC

Compliance & RUO Disclaimer

For laboratory research use only (RUO). Not a drug, food, or cosmetic. Not for human or veterinary use. Purchase and use are limited to qualified personnel operating under institutional laboratory guidelines.