Overview

N‑Acetyl Semax 10 mg (Ac‑Semax; Ac‑MEHFPGP) from Peptide Tech is a premium, lyophilized research‑use‑only (RUO) heptapeptide supplied at ≥99% purity (HPLC & MS verified). This N‑terminally acetylated Semax analog — Ac‑Met‑Glu‑His‑Phe‑Pro‑Gly‑Pro — is formatted for reproducible in‑vitro neuropeptide signaling, BDNF/TrkB‑axis readouts, and analytical method development under rigorous documentation and cold‑chain integrity.

Specifications

Property	Details
Product	N‑Acetyl Semax — lyophilized peptide, 10 mg
Chemical Name	Ac‑MEHFPGP (Ac‑Met‑Glu‑His‑Phe‑Pro‑Gly‑Pro)
Synonyms	Ac‑Semax; NAS; N‑Acetyl‑Semax; Ac‑MEHFPGP
Sequence	Ac‑Met‑Glu‑His‑Phe‑Pro‑Gly‑Pro (Ac‑MEHFPGP)
C‑terminus	Free acid by default (amidated variant — “N‑Acetyl Semax Amidate / NASA” — available on request). Confirm on COA.
CAS Number	Not assigned for this exact variant
PubChem CID	No consolidated PubChem entry exists for N‑acetylated Semax. See native Semax listing for reference.
Molecular Formula	Free acid (nominal): C₃₈H₄₉N₉O₁₀S (estimate; verify on COA). Amidated variant will differ.
Molecular Weight	Free acid (nominal): ≈ 811–815 g/mol depending on counter‑ion. Verify on COA.
Appearance	White to off‑white lyophilized powder
Container	3 mL Type I glass vial; butyl stopper; flip‑off seal
Purity / Identity	≥99% by HPLC; identity by MS (batch COA via on‑vial QR)
Counter‑ion	Typically acetate (verify on lot COA)
Solubility	Soluble in sterile water or neutral buffers; for rapid wetting at higher concentration, pre‑wet with ≤0.1% acetic acid then bring to buffer. Filter (0.22 µm) if sterility is required by your SOP.
Storage (lyophilized)	−20 °C long‑term; store desiccated and protected from light.
After Reconstitution	Aliquot and store at ≤ −20 °C (or −80 °C per SOP); avoid repeat freeze–thaw cycles.
Intended Use	RUO only. Not for human or animal use.

Molecular Structure

A dedicated PubChem 2D image for N‑Acetyl Semax is not currently available. If you need a drawn structure for reports, contact support for an SVG based on the exact lot (free acid vs amidate; counter‑ion).

Note: Structural formulae and exact mass vary with terminal amidation and counter‑ions. Confirm on the lot COA.

Key Features of Peptide Tech

Same‑Day Shipping (Mon–Fri, on in‑stock items)
GMP‑Aligned lyophilization & documentation
USA‑Made peptides
24/7 Support & Price Match Guarantee
Batch QR for instant COA & chain‑of‑custody verification
3rd‑Party U.S. Lab Testing — purity, quantity, endotoxin
Cold‑Chain Shipping — Always (no paid upgrade)
Worldwide Shipping; all major payments accepted
Text & Email order updates; 2‑Day FedEx/UPS standard with low‑cost overnight
Largest Variety of peptides & bioregulators

Potential Applications in Research (RUO)

Strictly for laboratory research. No health, diagnostic, or therapeutic claims.

Neurotrophin‑axis readouts — quantify BDNF/TrkB pathway markers (mRNA/protein) in neuronal or glial cultures following defined Ac‑Semax exposures (RT‑qPCR, ELISA, Western).
cAMP/PKA and CREB signaling — measure phospho‑CREB and immediate‑early genes under serum‑controlled conditions with time‑course dosing.
Oxidative‑stress panels — evaluate ROS assays, antioxidant response genes (e.g., Nrf2/HO‑1), and mitochondrial potential under standardized oxidative challenges.
Peptide stability & transport — establish stability in CSF‑like buffers; assess uptake/transport across in‑vitro barrier models (e.g., hCMEC/D3).
Analytical method development — RP‑HPLC/LC–MS(/MS) for identity, purity, recovery, and forced‑degradation profiling across buffers and temperatures.

Citations (selected)

Alekseeva, K. I., et al. Reports on Semax family peptides modulating BDNF/TrkB and neuroprotective signaling in cell‑based models (review context).
General GPCR/CREB pathway assay methods and oxidative‑stress protocols in neuronal cell culture (standard Methods in Molecular Biology / JOVE‑style references).

Quality, Storage & Handling

Every lot is confirmed by HPLC (purity) and MS (identity); the on‑vial QR links to the batch COA. Independent U.S. labs verify purity, quantity, and endotoxin.

Storage (lyophilized): −20 °C long‑term or 2–8 °C short‑term; keep desiccated and protected from light.
After reconstitution: Aliquot promptly; store at ≤ −20 °C (or −80 °C per SOP). Avoid multiple freeze–thaw cycles.
Reconstitution tips: Use sterile water or suitable buffer; gently swirl/invert to dissolve. If sterility is required, 0.22 µm filter and aliquot.

Shipping & Fulfillment

Ships with validated cold‑chain packaging. In‑stock orders placed before the daily cutoff ship the same day. 2‑Day FedEx/UPS is standard, with overnight options available. Automated text/email updates included; international shipping available where permitted.

Compliance & RUO Disclaimer

For laboratory research only. Not a drug, cosmetic, food, or household chemical. Not for human or animal use, ingestion, diagnostic, or therapeutic applications. Purchasers warrant appropriate qualifications and compliance with applicable regulations and institutional policies.

FAQs

Is this the same as “N‑Acetyl Semax Amidate (NASA)?”: No. This listing is N‑Acetyl Semax (free acid) unless the COA states otherwise. The amidated variant adds a C‑terminal –NH₂. If you need NASA, ask about custom lots.
Do you provide a PubChem image?: PubChem does not currently host a dedicated 2D rendering for N‑Acetyl Semax. We can supply a structure file (SVG/MOL) for your lot on request.
What purity do you provide?: Each 10 mg vial is ≥99% by HPLC with MS identity confirmation; third‑party testing is performed on every lot (COA via on‑vial QR).
How should I reconstitute it?: Dissolve in sterile water or a compatible buffer; gently invert until fully dissolved. If your SOP requires sterility, 0.22 µm filter and aliquot to avoid repeat freeze–thaw.